Essay on Parkinson Disease (PD) - 2171 Words

Introduction Parkinson disease (PD) is a progressive neurodegenerative disorder characterized mainly by physical and psychological disabilities. This disorder was named after James Parkinson, an English physician who first described it as shaking palsy in 1817 (Goetz, Factr, and Weiner, 2002). Jean- Martin Charcot, who was a French neurologist, then progressed and further refined the description of the disease and identified other clinical features of PD (Goetz, Factr, and Weiner, 2002). PD involves the loss of cells that produce the neurotransmitter dopamine in a part of the brain stem called the substansia nigra, which results in several signs and symptoms (Byrd, Marks, and Starr, 2000). It is manifested clinically by tremor,†¦show more content†¦Although many theories and hypotheses were raised as to why this happens, there is no solid information supporting the physiological cause of this, but it is surely one of various factors that may lead to the development of PD. Neuroanatomy of the Basal Ganglia It has been known that PD is a disorder affecting the basal ganglia. The term basal ganglia is generally applied to a collection of nuclei situated deep within the cerebral hemispheres, lying laterally to the thalamus (Gazzeniga, George, and Mangun, 2008). The basal ganglia are important subcortical structures. They are composed of five nuclei: caudate, putamen, globus pallidus, subthalamic nucleus, and substantia nigra. These nuclei are not thought of a single anatomical entity; rather, they form a functional unity whose contribution is greatly to motor control. Interestingly, this system does not influence movement through spinal cord pathways, but rather acts as part of a feedback loop to all areas of the cerebral cortex, with primary input into motor areas (Aird, 2000). A number of excitatory and inhibitory neurotransmitters are what control this whole process, and a balance of both is required to ensure that smooth, purposeful movement takes pla ce. In order to understand the pathways of which the basal ganglia take part in, it is essential to know the input and output connections of the basal ganglia. The inputShow MoreRelatedParkinson Disease ( Pd )1350 Words   |  6 Pages Parkinson disease (PD) is one of the most common neurologic disorders. and it affects approximately 1% of individuals older than 60 years old. Parkinson’s disease is a condition that progresses slowly by treatment. In addition, loss of pigmented dopaminergic neurons of the substantianigra pars compacta and the presence of Lewy bodies and Lewyneurites are the two major neuropathologic findings in Parkinson disease (Hauser, 2016). The cause of Parkinson disease, defined by Robert Hauser, who isRead MoreParkinson Disease ( Pd )929 Words   |  4 PagesParkinson Disease (PD) is a neurodegenerative disease symptomized by tremor, muscular rigidity, and slow imprecise movements. Typically, the disease affects middle-aged and elderly individuals. PD is associated with degeneration of the basal ganglia of the brain causing a deficiency of the neurotransmission of dopamine. (1). Given what you know about the members of the family, analyze and comment on the potential effects this condition/illness might have on them. Since Mr. Olsen (Frederic) hasRead MoreParkinson s Disease ( Pd )1361 Words   |  6 PagesParkinson’s disease (PD) is a neurodegenerative disease which is progressive, incurable and debilitating. The disease is caused by a loss of dopamine producing neurons in the brainstem which leads primarily to motor deficits. In Australia, 1 in 350 people live with PD and the prevalence is quickly growing (Parkinson s Queensland, 2014). While most of the people diagnosed with PD are over 65 years old, people as young as 30 can develop the condition (Parkinson s Queensland, 2014). Currently, thereRead MoreThe Parkinson s Disease ( Pd )1058 Words   |  5 PagesIntroduction The Parkinson s disease (PD) is the second most common neurodegenerative disorder after Alzheimer s disease (Lang and Lozano, 1998). It affects about 1% of the population with different ethnic backgrounds throughout the world over the age of 65 (Tanner and Goldman, 1996). The aetiology of Parkinson s disease is not well understood; however, genetic and environmental factors are thought to play a role (Checkoway and Nelson, 1999). Pathologically, PD is characterised by mitochondrialRead MoreAnalysis Of Parkinson s Disease ( Pd )725 Words   |  3 Pages Introduction Parkinson s disease (PD) is the second world s major neurological disease (Laut Breteler, 2006) affecting 6 million people globally (Schapira, 1999). PD is a progressive and long term disorder of the central nervous system (CNS) activity with the following traits including bradykinesia, rigorousness, involuntary muscular contraction and unstable postural alignment (O Sullivan Schmitz, 2007). Basal ganglia are located in the CNS have large nerve fibers and neurotransmittersRead MoreAnalysis Of Parkinson s Disease ( Pd )1890 Words   |  8 Pagesthe salient characteristics associated with Parkinson’s disease (PD) are most commonly linked to motor deficits, including tremor and rigidity, a majority of individuals with PD also experience a variety of sensorimotor speech deficits. While listeners often describe the speech of individuals with PD as unnatural or unintelligible, reflecting many of the phonatory, articulatory, and prosodic deficits linked to the disorder, in dividuals with PD tend to minimize or even deny their speech differencesRead MoreParkinson s Disease ( Pd )1326 Words   |  6 Pages Parkinson’s disease (PD) is one of the most frequent neurodegenerative diseases, falling second to Alzheimer’s disease. It is stated that there are roughly 5 million individuals worldwide and 1 million individuals in the U.S. that suffer from PD. PD arises from the lack of dopamine in the brain along with the degradation of dopaminergic neurons, particularly in the substantia nigra pars compacta.1 The degradation of the dopamine neurons increases the number of free radicals in the substantia nigraRead MoreParkinson s Disease ( Pd )822 Words   |  4 PagesParkinson’s disease (PD) is a neurodegenerative disorder characterized by aberrant ÃŽ ±-synuclein aggregates within neurons causing damage or neuronal death in different regions of the brain with most disease development occurring in the substantia nigra (NIH.PARK). ÃŽ ±-synuc lein positive Lewy bodies are another hallmark of PD development (NIH.PARK). Damage or death of neurons leads to a decrease in dopamine production which is required for smooth control of muscle movement (NIH.PARK2, NIH.PARK). ClinicallyRead MoreParkinson s Disease ( Pd )951 Words   |  4 PagesParkinson’s disease (PD) is a neurodegenerative debilitating movement disease which gets worse over time (Medscape, 2015). After much research and study no known cause has yet been determined and experts have hypothesized that it is a mix of inherited and environmental factors (Medscape, 2015). However, regardless of the unspecific cause, it is characterized by a significant loss in dopamine transportation to the basal ganglia which manifests itself in the three following physiologic signs: restingRead MoreEarly Parkinson s Disease ( Pd ) Through The Characteristics Of Finger Movement During Typing Essay5181 Words   |  21 Pagesresearch into detecting early Parkinson’s Disea se (PD) through the characteristics of finger movement during typing. It begins with a discussion of PD and its symptoms, and then provides an overview of the current and emerging diagnostic strategies for early detection of the disease, with particular emphasis on those involving human-computer interaction (HCI) and the relationship with keystroke biometrics. The scope of the review is to focus on the motor symptoms of PD, rather than the causes, pathogenesis